Amino-PEG3-Azide With Cas.134179-38-7 Is For Chemical Modifications

Synonyms:

1 - Amino - 11 - azido - 3 , 6 , 9 - trioxaundecane, 2 - { 2 - [ 2 - ( 2 -Azidoethoxy ) ethoxy ] ethoxy } ethylamine, O - ( 2 - Aminoethyl ) - Oμ - ( 2 - azidoethyl ) diethylene glycol ; 1 - Amino - 11 - azido - 3 , 6 , 9 - trioxaundecane ; 11 - Azido - 3 , 6 , 9 - trioxaundecane - 1 - amine ; N3 - PEG3 - CH2CH2NH2 ; 11 - Azido - 3 , 6 , 9 - trioxaundecylamine ; 2 - { 2 - [ 2 - ( 2 - Azidoethoxy ) ethoxy ] ethoxy } ethylamine ,  1 - Amino - 11 - azido - 3 , 6 , 9 - trioxaundecane ; 1 - Amino - 11 - azido - 3 , 6 , 9 -trioxaundecane 11 - Amino - 3 , 6 , 9 - trioxaundecanyl Azide ; 11 - Azido - 3 , 6 , 9 - trioxaundecan - 1 - aMine.

Introduction

The Amino-PEG3-Azide With Cas.134179-38-7 is used for modifying proteins or surfaces such as beads, nanoparticles and self-assembled monolayers. Modification of proteins adds polyethylene glycol (PEG)_n spacers, which impart increased water solubility, reduced immunogenicity of the labeled molecule and enhanced in vivo stability in solution. Functionalization of solid surfaces, such as quantum dots, self-assembled monolayers and nanoparticles, with polyethylene glycol spacers significantly reduces nonspecific protein binding. (PEG)n amine reagents used with (PEG)n amine reagents in surface modification can form a hydrophilic “lawn” of methyl ether-terminated PEGs with periodic exposed carboxy-terminated PEGs. The exposed carboxy groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulfo-NHS.

Typical PEGylation reagents contain heterogeneous mixtures of different PEG chain lengths; however, our PEGylation reagents are homogenous compounds of defined molecular weight and spacer length, providing precision in optimizing modification applications.

Important Product Information

? The Amino-PEG3-Azide With Cas.134179-38-7 is low-melting solids that are difficult to weigh and dispense. To facilitate handling, make a stock solution by dissolving the reagent with dimethylsulfoxide (DMSO) or dimethylformamide (DMF).

? Use the (PEG)n amine reagents in combination with (PEG)n amine reagents to modify surfaces and minimize nonspecific binding.

? Use non-amine-containing buffers at pH 7-9 such as PBS (20mM sodium phosphate, 150mM NaCl; pH 7.4); 20mM HEPES; 100mM carbonate/biocarbonate; or 50mM borate. Do not use buffers that contain primary amines, such as Tris or glycine, which compete with acylation.