THP-PEG7-t butyl ester is a polyethylene glycol (PEG) derivative containing a tetrahydrofuran ether (THP) protecting group and a t-butyl ester group, with a molecular formula of C₂₃H₄₆O₉ and a molecular weight of approximately 454.6. Its structure consists of a seven-unit polyethylene glycol (PEG7) chain connecting the THP protecting group and the t-butyl ester group. The THP group is used to protect hydroxyl groups, while the t-butyl ester group can be deprotected under acidic conditions to generate a carboxyl group. The production process includes synthesizing a low-molecular-weight PEG chain, introducing disulfide bonds, connecting the t-butyl ester group via esterification, and finally incorporating the THP protecting group. This compound is primarily used in drug synthesis as a protecting group or as a hydrophilic spacer to enhance molecular water solubility, and it is applicable for material surface modification and lipidic assembly research.