MS-PEG6-THP (CAS No.: 42607-89-6) is a PROTAC linker based on hexaethylene glycol (PEG6), with the molecular formula C₁₈H₃₆O₁₀S and a molecular weight of 444.54. Its structure consists of three parts: a PEG chain, methanesulfonyl group (Ms), and tetrahydrofuran ether (THP). The PEG chain provides flexibility and water solubility, the Ms group serves as a reactive site, and the THP terminal group enhances stability. The production process typically employs chemical synthesis methods to achieve high-purity (≥95%) linear structures by controlling reaction conditions. This product is primarily used in PROTAC molecule development, where it connects E3 ubiquitin ligase ligands with target protein ligands to induce target protein degradation. It holds significant application value in cancer therapy and signal pathway research.