Bis-propargyl-PEG17 is a PEG-based PROTAC linker with the molecular formula C₃₆H₇₀O₁₇ and a molecular weight of 774.93. Its structure features propargyl groups (Alkyne) at both ends, connected by a flexible chain segment composed of 17 ethylene glycol units. It can efficiently couple with molecules containing azide groups via copper-catalyzed azide-alkyne cycloaddition (CuAAC). The production process involves esterifying polyethylene glycol with p-toluenesulfonyl chloride to generate a sulfonate ester intermediate, followed by an amidation reaction to introduce the propargyl group. The process yields stable results with a purity of over 98%. This reagent is widely used in PROTAC molecule synthesis, where it connects E3 ubiquitin ligase ligands with target protein ligands to enable targeted protein degradation, holding significant academic value in cancer therapy and signal pathway research.