产品展厅
甲基-五聚乙二醇-羧酸
2021-02-20
产品详情
- 产地 武汉
- Cas：1347750-72-4
- 产品名称甲基-五聚乙二醇-羧酸
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- 简介
Methyl-PEG5-acid (CAS: 1347750-72-4) is a linear polyethylene glycol (PEG) derivative with the molecular formula C₁₄H₂₈O₉ and a molecular weight of approximately 340. Its structure consists of a pentaglyme chain terminated with a methoxy group (MPEG5) and an end carboxylic acid group (COOH), combining a hydrophilic PEG chain with a reactive carboxylic acid terminal group.
The production process typically involves ring-opening esterification of methoxypolyethylene glycol with maleic anhydride, catalyzed by pyridine. The reaction is carried out at 125°C for 6 hours, followed by ether purification to obtain a high-purity product. The carboxylic acid group can be activated with EDC/NHS to form amide bonds with amines or directly participate in esterification reactions.
This product is widely used in the biomedical field, such as drug carrier modification, antibody-drug conjugate (ADC) linkers, surface functionalization of nanomaterials, and polymer material modification (e.g., enhancing coating adhesion). Its low immunogenicity and high water solubility significantly improve the biocompatibility of materials.
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