m-PEG36-alcohol (CAS: 2633587-48-9) is a high-purity, monodispersed polyethylene glycol (PEG) derivative. It is a white solid with a molecular weight of approximately 1617.93 g/mol. This compound features a methoxy group (-OCH3) at one end and a hydroxyl group (-OH) at the other, connected by a linear chain of 36 ethylene glycol units. Its key properties include excellent hydrophilicity and biocompatibility, making it a valuable building block in various chemical and biological applications.

This versatile molecule finds extensive use in advanced chemical and biological research. Its primary applications span across the fields of drug discovery, bioconjugation, and material science. It is particularly crucial in the development of targeted therapeutics and the modification of biomolecules to enhance their performance in biological systems.

The main uses of m-PEG36-alcohol are diverse. It serves as a hydrophilic PEG linker in the synthesis of PROTACs (Proteolysis Targeting Chimeras), facilitating the selective degradation of target proteins. Additionally, it is widely employed as a PEGylation reagent to modify proteins, peptides, and antibodies, thereby improving their solubility, stability, and circulation half-life while reducing immunogenicity. It is also utilized in the development of drug delivery systems, nanoparticles, and hydrogels for biomedical applications.